Reflection

According to the study, the establishment of the six hallmarks provided the clear understanding of the neoplastic disease diversification. The primary goal of the study determined the concept of understanding the fact that normal cells do evolve to the neoplastic state through sequential steps which have been highlighted as the six hallmarks. The tumor growth has been the anticipated proposition about the insular masses of the proliferating cancer cells. The understanding of the biology of tumor that is associated with the definition of the biology of cancer requires concentration and consideration of the contributors to the growth of the tumor microenvironment. Cancer is a disease that has not been well understood to enable the researcher and scientist to develop the possible treatment of the complication that is associated with the interference of the body DNA and mostly diagnosed with the tumorigenesis conditions. The study gives a better description and sheds more in regards to the disease.

Hallmark capability has given a good impact in the process of developing the cancer research such that the observations made from the research have raised the eyebrows in regards to the concepts that defines the hallmark traits. The understanding of the biology of cancer has been building on the establishment and studying of the six hallmarks. In a normal condition, the tissues do always take control of the signal production and release that initiates the progression of the cell growth. The homeostasis of the cell number is maintained meeting the normal tissue functions and architecture. Whilst in a cancer case, there is no the deregulation of the signals hence the abnormal growth of the tissue with a deformed architecture that sees the realization of an increase in the cell size as proclaimed.

The study further outlines that, mutations of the cells do vary in regards to the signals controlling. The growth factor receptors play a role in defining the protein mutation. The signal transmission within the body defines the development of the body tissues hence the signal powers are such great in regards to the attenuated proliferative signaling. As a matter controlling the cancer cell growth, there was the consideration of evading the growth suppressors. Probably possible well-defined programs should get set to negatively control and regulate the cell proliferation for the cancer cells. Therefore, the tumor suppressors do work in the way of limiting and controlling the cell growth. Cell growth suppression depends on the kind of the cell as the practice may initiate the tumor growth and hence the controlling gets beyond the manageable levels. The TP53 and RB canonical suppressors of proliferation are significant in providing regulation of the cell proliferation.

Contact inhibition also plays a good part in ensuring the cell proliferation suppression. This contact inhibition acts as a vitro surrogate mechanism. The noted way of controlling the development of cancer is by resisting the cell death via the establishment of the programmed cell death by the apoptosis way of inhibiting. The apoptosis machinery has the trigger that controls the signal between the effectors and the regulators thus suppressing the underway interactions and growth.

Tumors require almost same favorable conditions just as a normal tissue wills the provision of nutrients and oxygen for the sustenance of its form and as well evacuate the metabolic wastes and the carbon ii oxide. Subsequently, the telomerase has been apparently defined of being relevant in playing a good role in cell proliferation. The research and study of the six hallmarks are quite significant in providing a good understanding of the cancer cells and the associated processes since cancer has become a global epidemic.

Sherry Roberts is the author of this paper. A senior editor at MeldaResearch.Com in affordable custom writing if you need a similar paper you can place your order for medical essay writing service online.